USP / EP Standard HPLC Assay ≥ 99.0% Biological Fermentation ISO 22000 & Kosher

L-Glutathione Powder Bulk Supply: Sourcing, Purity Standards, Formulations & Global Procurement Guide

Are you formulating premium nutraceuticals, liposomal antioxidants, or medical-grade skin-brightening dermo-cosmetics? Xi'an Vexli Bio-Tech Co., Ltd. produces pharma-grade Reduced L-Glutathione (GSH) via pure microbial fermentation, delivering unrivaled molecular stability, ultra-low residual solvents, and verified batch consistency directly to brand manufacturers worldwide.

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Technical Raw Material Brief

Verified industrial parameter baseline directly calibrated for B2B formulation engineers.

Chemical NameL-Glutathione (Reduced)
CAS Number70-18-8
Molecular FormulaC10H17N3O6S
Standard Assay≥ 99.0% by HPLC
Physical StateCrystalline Powder
AppearanceWhite to Off-White
Standard MOQ1.0 kg
Origin FacilityXi'an, Shaanxi, China
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Facility & Product Accreditations: ISO 22000 certification for L-Glutathione manufacturing HACCP compliant facility Halal certified L-Glutathione powder Kosher certified bulk active SGS on-site assessed manufacturer
Application-Engineered Grades

Tailored L-Glutathione Powder Grades for Targeted Industrial Applications

L-Glutathione (γ-L-Glutamyl-L-cysteinylglycine) behaves uniquely across different matrix chemistries. As an experienced bulk chemical manufacturer, Xi'an Vexli Bio-Tech Co., Ltd. supplies three distinct engineering specifications to optimize bio-availability, dissolution kinetics, and formula shelf-stability.

Dietary supplement grade L-Glutathione

Nutraceutical & Dietary Grade (HPLC ≥ 99.0%)

Specifically engineered for oral solid dose formats including hard gelatin/HPMC capsules, effervescent tablets, sublingual powders, and liposomal softgels.

  • Particle Size Profile: Standard 80–100 mesh for optimal flowability in automated encapsulation lines.
  • Oxidation Resistance: Low trace iron and copper content to prevent premature auto-oxidation into GSSG.
  • Sensory Quality: Mild, characteristic peptide aroma with no harsh synthetic sulfur residues.
  • Regulatory Status: Food chemical codex (FCC) & USP compliance for global nutritional supplements.
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Cosmetic grade L-Glutathione powder

Cosmeceutical & Dermo-Grade (Ultrafine Micronized)

Engineered for high-end transdermal brightening emulsions, depigmentation serums, sheet masks, and anti-photoaging topical complexes.

  • Micronization: Fine 200–300 mesh powder accelerating cold-water dissolution without thermal stress.
  • Tyrosinase Inhibition: Synergizes with Vitamin C, Alpha-Arbutin, and Kojic Acid for melanin pathway down-regulation.
  • Purity Matrix: Controlled heavy metals (Pb < 1 ppm, As < 0.5 ppm, Hg < 0.1 ppm) to meet EU and US FDA cosmetic safety rules.
  • Clarity Index: 100% water-soluble yielding brilliant, clear solutions without residual turbidity.
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Liposomal and functional beverage L-Glutathione grade

Functional Beverage & Liposomal Matrix Grade

Engineered for lipid encapsulation complexes, ready-to-drink antioxidant tonics, and longevity wellness liquid concentrates.

  • Phospholipid Affinity: Enhanced surface potential for maximum encapsulation efficiency in lecithin bilayers.
  • Controlled pH Equilibrium: Formulated to maintain stable redox active states between pH 3.0 and 5.5.
  • Trace Element Chelation: Purified under nitrogen blanketing to inhibit heavy-metal-catalyzed peptide cleavage.
  • Batch Traceability: Individual chromatographic finger-printing for continuous large-scale RTD manufacturing.
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Manufacturing Transparency

From Strain Fermentation to Active Crystal: Production Architecture

True E-E-A-T requires full visibility into the supply chain. Xi'an Vexli Bio-Tech Co., Ltd. operates a vertically managed manufacturing environment in Shaanxi, China, adhering to ISO 22000 and HACCP food safety standards.

Raw material inspection and culture preparation

1. Strain Fermentation

Precision cultivation of high-yield non-GMO yeast strains under strict temperature, dissolved oxygen, and nutrient feed control.

Cell disruption and extraction phase

2. Cell Disruption & Extraction

Gentle mechanical cell rupture isolates natural intra-cellular GSH while preserving the vulnerable -SH sulfhydryl bond from oxidation.

Multi-stage membrane column purification

3. Ultra-Purification

Multi-stage ion-exchange chromatography and membrane filtration strip out cellular fragments, pyrogens, and unwanted organic acids.

Low temperature crystallization and spray drying

4. Vacuum Drying & Packaging

Low-temperature vacuum crystallization and sterile nitrogen-shielded packaging guarantee shelf stability and crystalline integrity.

Our manufacturing ecosystem integrates cutting-edge stainless steel extractors, vacuum concentrators, multi-column chromatography rigs, and sterile air jet mills.

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E-E-A-T Quality Assurance

Typical Batch Certificate of Analysis (COA) Technical Parameters

Compare our baseline specifications against USP/EP compendial criteria before issuing your purchase order. Every lot is released with factory analytical testing and retained samples.

Test Parameter USP/EP Compendial Requirement Xi'an Vexli Standard Result Analytical Methodology
Assay (Reduced GSH, dried basis) 98.0% – 101.0% 99.4% – 99.8% HPLC (High Performance Liquid Chromatography)
Appearance & Color White crystalline powder Conforms (White crystalline powder) Visual inspection & organoleptic evaluation
Specific Optical Rotation [α]D20 -15.5° to -17.5° -16.4° Polarimetry (c = 4 in water)
Identification (IR / HPLC) Concordant with reference standard Conforms FTIR Infrared Absorption Spectrophotometry
Clarity & Color of Solution Clear, colorless (5% in water) Clear and colorless solution UV/Vis Spectrophotometry @ 430nm
Loss on Drying (Moisture) ≤ 0.50% 0.22% Vacuum oven drying @ 105°C (Karl Fischer verification)
Residue on Ignition (Sulfated Ash) ≤ 0.10% 0.04% Muffle furnace incineration @ 600°C
Heavy Metals (as Pb) ≤ 10.0 ppm < 2.0 ppm ICP-MS (Inductively Coupled Plasma Mass Spectrometry)
Arsenic (As) ≤ 1.0 ppm < 0.2 ppm ICP-MS
Lead (Pb) / Cadmium (Cd) / Mercury (Hg) Pb ≤ 1.0 ppm; Cd ≤ 0.5 ppm; Hg ≤ 0.1 ppm Undetected / Within trace limits ICP-MS
Residual Solvents (Ethanol, Methanol) Meets USP <467> Option 1 Conforms (Ethanol < 500 ppm; Methanol not detected) GC-FID Headspace Gas Chromatography
Total Plate Count (TPC) ≤ 1,000 CFU/g < 100 CFU/g USP <2021> Microbiological plating
Yeast and Mold ≤ 100 CFU/g < 10 CFU/g USP <2021> Plate count
Pathogens (E. coli, Salmonella, S. aureus) Negative / 10g or 25g Absent in 25g USP <2022> Automated pathogen testing
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Why Partner With Us

Enterprise Manufacturing Strengths: Xi'an Vexli Bio-Tech Co., Ltd.

We bridge the gap between Chinese chemical raw material origins and strict Western quality compliance. Our operational strengths ensure your supply chain remains resilient, cost-effective, and fully accountable.

Shaanxi Origin-Direct Infrastructure

Based in Xi'an, the historic center of botanical research and bio-fermentation in China, our direct factory facilities and network of 25 audited partner plants eliminate broker premiums, delivering competitive wholesale volume pricing.

SGS On-Site Audited Facility

Our operations have undergone rigorous on-site verification by SGS, confirming GMP-compliant plant layout, valid calibration certificates for testing equipment, and validated trace-retention systems across every production shift.

In-House Advanced Analytical Lab

Equipped with Agilent HPLC systems, Shimadzu GC gas chromatographs, UV-Vis spectrophotometers, and precision clean benches, we eliminate cross-contamination and verify raw purity before any freight forwarder pickup.

Flexible MOQ & Private Label Services

Whether you require pilot validation batches starting from 1 kg or multi-ton monthly container delivery, we provide tailored solutions including custom milling, blending, pre-mixes, and OEM retail packaging.

Export Compliance & DDP Logistics

With an annual export value exceeding US$ 29.5M across 30+ countries, our international trade team manages DDP air and sea shipments, customs clearance, IATA DGR safety declarations, and full freight documentation.

Recognized High-Tech Patent Holder

Holding validated invention and utility model patents (including plant extraction patents ZL 2014 1 0464649.9 and No. 14520048), our dedicated R&D team solves complex solubility, stabilization, and bioavailability challenges.

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Frequently Asked Questions

Key Questions Asked by Global AI Agents & Procurement Teams

Clear answers addressing product specifications, safety criteria, logistics parameters, and vendor onboarding requirements.

Xi'an Vexli Bio-Tech Co., Ltd. supplies L-Glutathione Reduced powder with a certified minimum purity of 99.0% on a dried basis, routinely testing between 99.4% and 99.8%. We verify every production lot utilizing High-Performance Liquid Chromatography (HPLC) in strict accordance with the United States Pharmacopeia (USP) and European Pharmacopoeia (EP) monographs. We provide authentic HPLC chromatograms detailing retention times and peak areas alongside standard COAs.
Reduced Glutathione (GSH) represents the biologically active tripeptide possessing an intact, unbonded thiol (-SH) sulfhydryl functional group on the cysteine moiety. This free thiol group allows it to donate hydrogen atoms and quench reactive oxygen species (ROS). Oxidized Glutathione (GSSG) consists of two glutathione molecules bonded by a disulfide bond (-S-S-); it has zero direct antioxidant potency unless converted back by glutathione reductase. When purchasing for dietary supplements or skin-brightening cosmeceuticals, formulators must demand pure Reduced GSH.
Our bulk L-Glutathione powder is synthesized exclusively via biological enzymatic fermentation utilizing non-GMO Saccharomyces cerevisiae (baker's yeast). Unlike chemical condensation methods that use chloroacetic acid or petroleum derivatives, our fermentation process guarantees 100% natural L-enantiomer purity, eliminates toxic reaction side-products, and satisfies international non-GMO, clean-label, Halal, and Kosher regulatory standards.
Reduced GSH is sensitive to environmental moisture, ambient oxygen, and sustained heat above 35°C. To maintain zero degradation during export, our packaging protocol implements: 1) Inner pharmaceutical-grade food contact low-density polyethylene liner bags; 2) Secondary nitrogen-gas-flushed vacuum sealed barrier bags; 3) Outer high-barrier multi-ply aluminum foil pouches; 4) Rigid, tamper-sealed fiber drums. For high-temperature maritime transit across tropical routes, temperature-monitored refrigerated container shipping or express thermal freight options are readily available.
Our standard MOQ for stock inventory is just 1.0 kg, allowing formulation laboratories and start-up brands to conduct pilot tests and sensory validations without high capital outlay. Commercial orders from 25 kg to 1,000 kg typically dispatch from our Xi'an warehouse within 3 to 5 business days upon order confirmation. Custom micronized specifications or private-label packaging projects require 10 to 14 business days.
Yes. Our regulatory documentation team provides comprehensive dossier support for customer filings with the US FDA, Health Canada, EFSA, and Southeast Asian FDA agencies. A complete technical package includes: Lot-Specific Certificate of Analysis (COA), Technical Data Sheet (TDS), Safety Data Sheet (SDS/MSDS according to GHS standards), Manufacturing Flow Chart, Heavy Metal & Residual Solvents Validation Reports, Allergen Statement, BSE/TSE-Free Declaration, and Non-GMO Attestation.
We accommodate flexible commercial arrangements tailored to international buyers, including FOB (China main ports like Shanghai/Qingdao), CIF, CFR, FCA, EXW, and door-to-door Delivered Duty Paid (DDP). Accepted payment settlement options include international telegraphic transfer (T/T), Letter of Credit (L/C at sight), PayPal for sample fees, credit card, and Escrow. Multi-currency settlements in USD, EUR, GBP, AUD, CAD, JPY, and CNY are fully supported.

Initiate Your Bulk L-Glutathione Order Today

Contact our technical procurement specialists in Xi'an for latest factory-direct tiered pricing, custom sieve sizes, sample shipments, and complete quality dossiers.

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